← Other recombinant proteins
Other recombinant protein
Other recombinant proteins · 39 findings (35 positive, 4 context-dependent)
What worked
MNS1 knockout →
increases LBA secretion
+ Positive MNL1 knockout →
increases LBA secretion
+ Positive SEC23 overexpression →
increases LBA secretion
+ Positive SAR1 overexpression →
increases LBA secretion
+ Positive ERV29 overexpression →
increases LBA secretion
+ Positive EMP47 overexpression →
increases LBA secretion
+ Positive BET1 overexpression →
increases LBA secretion
+ Positive PRB1 deletion →
increases LBA secretion
+ Positive HMX1 knockdown +
MNS1 deletion +
PRB1 deletion +
SEC23 overexpression +
SAR1 overexpression →
increases LBA secretion titer
+ Positive UGGT1 heterologous expression →
increases soluble and secretory glycoprotein production
+ Positive UGGT2 heterologous expression →
increases soluble and secretory glycoprotein production
+ Positive SEP15 heterologous expression +
UGGT1 heterologous expression →
increases glycoprotein production
+ Positive EDEM2 heterologous expression →
increases secretion
+ Positive HEM1 overexpression +
VAHB heterologous expression →
increases VaHB production
+ Positive OST1 other →
increases LBA secretion
+ Positive CAP heterologous expression →
increases soluble PCV3 cap protein production
+ Positive FTH1 heterologous expression →
increases recombinant ferritin heavy-chain yield
+ Positive MELITTIN heterologous expression →
increases melittin secretion
+ Positive PROMELITTIN heterologous expression →
increases promelittin secretion
+ Positive FTH heterologous expression →
increases recombinant ferritin heavy-chain yield
+ Positive LSC1 deletion +
SSN3 deletion →
increases LBA yield
+ Positive VP2 other →
increases vaccine protection against FJ-18 challenge
+ Positive INU1 knockout →
increases scFv production
+ Positive INU1 point mutation →
increases Est1E secretory expression
+ Positive INU1 point mutation →
increases secretory expression of other lignocellulolytic enzymes
+ Positive INU1 truncation →
increases promoter strength
+ Positive NS1 heterologous expression →
increases extracellular NS1 protein production
+ Positive GLUC point mutation →
increases secreted protein level
+ Positive LIF heterologous expression →
increases secreted protein yield
+ Positive GUS heterologous expression →
increases gus expression under tet-off promoter
+ Positive PHO610 truncation →
increases enzyme secretion
+ Positive LC1 heterologous expression +
INU1 heterologous expression →
increases LC1 secretion efficiency with INU signal peptides
+ Positive host Saccharomyces cerevisiae ·
Chung BH 1996 · ≈ 95 % (baseline 10 %, MFalpha1 leader peptide-containing vector) ·
detailsIL-2 heterologous expression +
INU1 heterologous expression →
increases IL-2 secretion with INU signal peptides
+ Positive INU1 heterologous expression →
increases alpha 1-antitrypsin secretion
+ Positive INU1 heterologous expression →
increases LC1 secretion efficiency
+ Positive
What failed or depended on conditions
TPI heterologous expression →
increases promoter activity
∼ Context-dependent HSA heterologous expression →
increases protein secretion
∼ Context-dependent GUS heterologous expression →
decreases Gus synthesis with doxycycline
∼ Context-dependent GUS heterologous expression →
increases Gus activity
∼ Context-dependent