INU1 heterologous expression: alpha 1-antitrypsin secretion
Positive AI-extracted, curator-verified MARXBASE-R000475
| Gene | INU1 Locus tag KLMA_10518 |
|---|---|
| Name in the paper | INU1A |
| Gene from | K. marxianus |
| Change | heterologous expression |
| Effect | increases |
| Phenotype | alpha 1-antitrypsin secretion (protein production) |
| Class | Positive |
| Host | Saccharomyces cerevisiae |
| Strain | not stated |
| Product | Other recombinant protein (Other recombinant proteins) |
Measured
| Value | ≈ 75 mg l-1 |
|---|---|
| Size as written | about 70% of total alpha 1-AT secreted; up to 75 mg l-1 in fed-batch |
| Metric | titer |
Conditions
| Process | fed batch |
|---|
Evidence
Evidence sentences are not included in this release.
Paper
High-level secretion of human alpha 1-antitrypsin from Saccharomyces cerevisiae using inulinase signal sequence.
Kang HA; Nam SW; Kwon KS; Chung BH; Yu MH
Journal of biotechnology 1996 · PubMed · DOI
Cite as: MarxBase result MARXBASE-R000475, release 1.0.