MarxBaseK. marxianus metabolic engineering results

Summary

What the collection holds, counting findings in K. marxianus host organisms only (433 findings from 130 papers; release 1.0). A multi-gene combination is one finding. These charts describe what abstracts report, which is not the same as what is true of the species: negative results are rarely reported.

Findings per phenotype category

354 positive, 58 negative and 21 context-dependent findings. The largest category is product formation with 123 findings.

product formationproduct formation: 116 positiveproduct formation: 5 negativeproduct formation: 2 context-dependent123protein productionprotein production: 43 positiveprotein production: 9 negativeprotein production: 7 context-dependent59stress tolerancestress tolerance: 38 positivestress tolerance: 8 negativestress tolerance: 1 context-dependent47genetic toolsgenetic tools: 39 positivegenetic tools: 5 negative44enzyme activityenzyme activity: 32 positiveenzyme activity: 4 negative36substrate utilizationsubstrate utilization: 28 positivesubstrate utilization: 7 negative35cell physiologycell physiology: 23 positivecell physiology: 7 negativecell physiology: 2 context-dependent32growthgrowth: 16 positivegrowth: 10 negativegrowth: 3 context-dependent29gene expressiongene expression: 17 positivegene expression: 2 negativegene expression: 6 context-dependent25otherother: 2 positiveother: 1 negative3
Findings per phenotype category, split by result class.
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CategoryPositiveNegativeContext-dependentTotal
product formation11652123
protein production439759
stress tolerance388147
genetic tools395044
enzyme activity324036
substrate utilization287035
cell physiology237232
growth1610329
gene expression172625
other2103

How often a type of change did not simply help

For each type of genetic change, the findings that were negative or context-dependent (orange) against positive ones (blue). A combination counts under each type it contains, so the totals add up to more than 433. Small counts mean wide uncertainty.

heterologous expression (n=103)heterologous expression (n=103): 94 positiveheterologous expression (n=103): 9 negative or context-dependent103knockout (n=100)knockout (n=100): 69 positiveknockout (n=100): 31 negative or context-dependent100overexpression (n=97)overexpression (n=97): 92 positiveoverexpression (n=97): 5 negative or context-dependent97deletion (n=45)deletion (n=45): 25 positivedeletion (n=45): 20 negative or context-dependent45point mutation (n=33)point mutation (n=33): 32 positivepoint mutation (n=33): 1 negative or context-dependent33mutagenesis evolution (n=18)mutagenesis evolution (n=18): 17 positivemutagenesis evolution (n=18): 1 negative or context-dependent18other (n=16)other (n=16): 13 positiveother (n=16): 3 negative or context-dependent16truncation (n=13)truncation (n=13): 9 positivetruncation (n=13): 4 negative or context-dependent13promoter swap (n=9)promoter swap (n=9): 4 positivepromoter swap (n=9): 5 negative or context-dependent9copy number increase (n=9)copy number increase (n=9): 9 positive9knockdown (n=5)knockdown (n=5): 5 positive5gene swap (n=5)gene swap (n=5): 5 positive5
Positive findings versus negative or context-dependent findings, by type of change.
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Type of changeFindingsNegative or context-dependentShare
heterologous expression10399%
knockout1003131%
overexpression9755%
deletion452044%
point mutation3313%
mutagenesis evolution1816%
other16319%
truncation13431%
promoter swap9556%
copy number increase900%
knockdown500%
gene swap500%

Papers per year

Papers with at least one finding in a K. marxianus host, by publication year (1993โ€“2026; 15 at most in a year).

048121993: 1 papers199319951996: 1 papers1997: 1 papers1998: 1 papers1999: 1 papers20002003: 1 papers2005: 1 papers20052007: 2 papers2008: 2 papers2009: 2 papers2010: 4 papers20102011: 1 papers2012: 2 papers2013: 5 papers2014: 5 papers2015: 6 papers20152016: 1 papers2017: 5 papers2018: 8 papers2019: 11 papers2020: 9 papers20202021: 9 papers2022: 9 papers2023: 3 papers2024: 12 papers2025: 12 papers20252026: 15 papers2026
Number of papers per publication year.
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YearPapers
19931
19940
19950
19961
19971
19981
19991
20000
20010
20020
20031
20040
20051
20060
20072
20082
20092
20104
20111
20122
20135
20145
20156
20161
20175
20188
201911
20209
20219
20229
20233
202412
202512
202615

Most studied products

The twelve products with the most findings, split by result class.

EthanolEthanol: 31 positiveEthanol: 2 negative33Other recombinant proteinOther recombinant protein: 29 positiveOther recombinant protein: 3 context-dependent32Secreted enzymeSecreted enzyme: 17 positiveSecreted enzyme: 9 negativeSecreted enzyme: 6 context-dependent32XylitolXylitol: 24 positiveXylitol: 1 negative25L-Lactic acidL-Lactic acid: 12 positiveL-Lactic acid: 2 context-dependent14Esters (ethyl acetate and other aroma esters)Esters (ethyl acetate and other aroma esters): 8 positive8Myo-inositolMyo-inositol: 5 positive5Pyruvate / PEPPyruvate / PEP: 5 positive5Succinic acidSuccinic acid: 5 positive52-Phenylethanol2-Phenylethanol: 4 positive4Acetic acid / acetateAcetic acid / acetate: 3 positiveAcetic acid / acetate: 1 negative4GlycerolGlycerol: 3 positiveGlycerol: 1 negative4
Findings per product, split by result class.
Show as a table
ProductPositiveNegativeContext-dependentTotal
Ethanol312033
Other recombinant protein290332
Secreted enzyme179632
Xylitol241025
L-Lactic acid120214
Esters (ethyl acetate and other aroma esters)8008
Myo-inositol5005
Pyruvate / PEP5005
Succinic acid5005
2-Phenylethanol4004
Acetic acid / acetate3104
Glycerol3104