Humanization of N-glycan-dependent protein quality-control system in Kluyveromyces marxianus promotes glycoprotein secretion.
Ai Y; He Y; Zhao L; Li M; Wang Y; Zhou J; Lu H; Yu Y
Metabolic engineering 2026 · China · PubMed · DOI
Results (5 findings)
UGGT1 heterologous expression →
increases soluble and secretory glycoprotein production
+ Positive UGGT2 heterologous expression →
increases soluble and secretory glycoprotein production
+ Positive SEP15 heterologous expression +
UGGT1 heterologous expression →
increases glycoprotein production
+ Positive EDEM2 heterologous expression →
increases secretion
+ Positive EDEM2 heterologous expression →
decreases endoplasmic reticulum-associated degradation
+ Positive
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