Xylitol

Sugar alcohols and polyols · 25 findings (24 positive, 1 negative)

What worked

ERG6 overexpression → increases xylitol titer Positive
host K. marxianus · strain YZB559 · Hu Z 2026 · 72.45 g/L 20% change · details
GSF2 deletion + MED15 overexpression → increases xylitol titer Positive
host K. marxianus · strain YZB639 · Hu Z 2026 · 74.13 g/L · details
GSF2 deletion + MED15 overexpression → increases xylitol titer Positive
host K. marxianus · strain YZB639 · Hu Z 2026 · 51.68 g/L · details
ERG6 overexpression → increases xylitol production Positive
host K. marxianus · strain NBRC 1777 · Ren L 2024 · 101.22 g/L · details
ERG6 overexpression → increases xylitol production Positive
host K. marxianus · strain NBRC 1777 · Ren L 2024 · 75.11 g/L · details
ERG6 overexpression → increases xylitol production in simultaneous saccharification and fermentation Positive
host K. marxianus · strain NBRC 1777 · Ren L 2024 · 45.98 g/L · details
UTR1 overexpression → increases xylitol production from glycerol Positive
host K. marxianus · strain YZB392 · Ren L 2022 · 3.3 g/L (baseline 2.5 g/L) · details
XYL1 heterologous expression → increases xylose reductase activity Positive
host K. marxianus · Zhang J 2022 · details
XYL1 overexpression + GAL2-N376F overexpression + ZWF1 overexpression → increases xylitol titer Positive
host K. marxianus · strain K. marxianus YZJQ016 · Zhang J 2022 · 105.22 g/L · details
GAL2_N376F overexpression → increases xylitol production Positive
host K. marxianus · Kwon DH 2020 · 26.55 g/l (baseline 7.03 g/l, parental) · details
GAL2_N376F overexpression → increases xylitol production rate Positive
host K. marxianus · Kwon DH 2020 · 360% change · details
XYL1 overexpression → increases xylitol yield Positive
host K. marxianus · strain IIPE453 · Dasgupta D 2019 · 1.62-fold · details
XYL1 heterologous expression → increases xylitol production from corncob hydrolysate Positive
host K. marxianus · strain YHY013 · Hua Y 2019 · > 100 g/L · details
XYL1 copy number increase → increases xylitol production Positive
host K. marxianus · strain CBS 6556 · Park JB 2019 · 440% change vs parental strain · details
XYL1 copy number increase → increases xylose reductase activity Positive
host K. marxianus · strain CBS 6556 · Park JB 2019 · 66% change vs parental strain · details
XYL1 copy number increase → increases xylitol productivity Positive
host K. marxianus · strain CBS 6556 · Park JB 2019 · 81% change vs parental strain · details
XYL2 mutagenesis evolution + XYL1 mutagenesis evolution → increases xylitol dehydrogenase activity Positive
host K. marxianus · strain KCTC17694 · Kwon DH 2019 · details
GXF1 heterologous expression → increases xylitol production Positive
host K. marxianus · strain YZJ017 · Zhang J 2015 · 147.62 g/L · details
XYL1 mutagenesis evolution → increases xylitol concentration Positive
host K. marxianus · strain K. marxianus ATCC 36907 · Kim JS 2015 · 120% change vs parental strain · details
XYL1 mutagenesis evolution → increases xylitol yield Positive
host K. marxianus · strain K. marxianus ATCC 36907 · Kim JS 2015 · 39% change vs parental strain · details
XYL1 heterologous expression → increases xylitol productivity Positive
host K. marxianus · strain YZJ015 · Zhang J 2014 · 1.49 g L(-1) h(-1) · details
XYL1 heterologous expression → increases xylitol titer Positive
host K. marxianus · strain YZJ015 · Zhang J 2014 · 60.03 g L(-1) · details
XYL2 knockout → increases xylitol titer Positive
host K. marxianus · strain YZJ017 · Zhang J 2014 · 100.02 g L(-1) · details
XYL1 gene swap → increases xylitol titer Positive
host K. marxianus · strain YZB014 · Zhang B 2013 · 11.32 g/l 2.7-fold · details

What failed or depended on conditions

XYL1 mutagenesis evolution + XYL2 mutagenesis evolution → no_effect xylose reductase activity Negative
host K. marxianus · strain KCTC17694 · Kwon DH 2019 · details