LAC12

Undetermined paralog MARXBASE-G000042

7 findings (6 positive, 1 negative).

Several K. marxianus loci carry this symbol. All candidate loci are recorded in gene_locus until the right one is determined (full text or supplement may be needed).

K. marxianus has several copies of this gene and the papers do not say which one was used.

Candidate loci

Undetermined: the papers do not say which copy was used.

• KLMA_20830 – lactose permease (annotation symbol matches; paper wording (PMID 23344501, 28444380, 30687296, 33937967) shares lactose)
• KLMA_30010 – sugar porter family MFS transporter (annotation symbol matches)
• KLMA_30728 – lactose permease (annotation symbol matches; paper wording (PMID 23344501, 28444380, 30687296, 33937967) shares lactose)
• KLMA_80005 – high-affinity glucose transporter (annotation symbol matches; paper wording (PMID 23344501, 28444380, 30687296, 33937967) shares glucose)

Results

growth (1 negative)

• LAC4 heterologous expression + LAC12 heterologous expression + NTH1 deletion + ATH1 deletion → decreases growth − Negative
  host Saccharomyces cerevisiae · strain AY-51024A · Zou J 2013 · details

product formation (2 positive)

• LAC4 heterologous expression + LAC12 heterologous expression + MIG1 deletion + NTH1 deletion → increases ethanol production from lactose in cheese whey + Positive
  host Saccharomyces cerevisiae · strain AY-5 · Zou J 2013 · 63.3 g l(-1) · details
• LAC4 heterologous expression + LAC12 heterologous expression → increases ethanol productivity from lactose + Positive
  host Saccharomyces cerevisiae · Domingues L 1999 · details

substrate utilization (4 positive)

• LAC4 overexpression + LAC12 overexpression → increases lactose uptake and conversion + Positive
  host Saccharomyces cerevisiae · Zou J 2021 · details
• LAC12 heterologous expression → increases galactose transport + Positive
  host Saccharomyces cerevisiae · Varela JA 2018 · details
• LAC12 heterologous expression → increases lactose uptake + Positive
  host Saccharomyces cerevisiae · Varela JA 2017 · details
• LAC4 heterologous expression + LAC12 heterologous expression → increases lactose metabolization + Positive
  host Saccharomyces cerevisiae · Domingues L 2001 · 50 g/L · details