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L-Lactic acid

Organic acids · 14 findings (12 positive, 2 context-dependent)

What worked

• SUA7 point mutation → increases lactic acid production + Positive
  host K. marxianus · Smets J 2025 · details
• PDC1 gene swap + LDHA heterologous expression → increases D-lactate titer + Positive
  host K. marxianus · Gosalawit C 2023 · 42.97 g/L · details
• LDH heterologous expression + LDH heterologous expression → increases l-lactic acid production + Positive
  host K. marxianus · Kong X 2019 · details
• JEN1 overexpression → increases l-lactic acid accumulation + Positive
  host K. marxianus · Kong X 2019 · details
• PFK overexpression → increases l-lactic acid accumulation + Positive
  host K. marxianus · Kong X 2019 · details
• DLD knockout → increases l-lactic acid accumulation + Positive
  host K. marxianus · Kong X 2019 · details
• PDC1 knockout → increases lactic acid production + Positive
  host K. marxianus · Bae JH 2018 · details
• LDH heterologous expression → increases lactic acid production + Positive
  host K. marxianus · Bae JH 2018 · details
• CYB2 deletion → increases lactic acid titer + Positive
  host K. marxianus · Bae JH 2018 · details
• DLD1 deletion → increases lactic acid titer + Positive
  host K. marxianus · Bae JH 2018 · details
• LDH heterologous expression + LDH heterologous expression → increases L-lactic acid titer + Positive
  host K. marxianus · Lee JW 2017 · 16 g/L (baseline 8.4 g/L) · details
• LDH heterologous expression → increases lactic acid concentration + Positive
  host K. marxianus · Pecota DC 2007 · details

What failed or depended on conditions

• LDH heterologous expression + LDH heterologous expression → increases L-lactic acid titer ∼ Context-dependent
  host K. marxianus · Lee JW 2017 · 24 g/L · details
• LDH heterologous expression + LDH heterologous expression → increases L-lactic acid yield ∼ Context-dependent
  host K. marxianus · Lee JW 2017 · 0.48 g/g · details