Improving the catalytic efficiency of aldo-keto reductase KmAKR towards t-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate via semi-rational design.

Yu H; Qiu S; Cheng F; Cheng YN; Wang YJ; Zheng YG
Bioorganic chemistry 2019 · China · PubMed · DOI

Results (1 findings)

• AKR point mutation → increases catalytic efficiency (kcat/Km) towards (5R)-1 + Positive
  host K. marxianus · Yu H 2019 · 2.64-fold vs M1 · details

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