AKR point mutation: catalytic efficiency (kcat/Km) towards (5R)-1
Positive AI-extracted, curator-verified MARXBASE-R000635
| Gene | AKR Enzyme or protein label, not a gene symbol |
|---|---|
| Gene from | K. marxianus |
| Change | point mutation |
| Effect | increases |
| Phenotype | catalytic efficiency (kcat/Km) towards (5R)-1 (enzyme activity) |
| Class | Positive |
| Host | K. marxianus |
| Strain | not stated |
Measured
| Value | 2.64-fold vs M1 |
|---|---|
| Size as written | 2.64-fold increase vs M1 |
| Metric | fold change |
Evidence
Evidence sentences are not included in this release.
Paper
Improving the catalytic efficiency of aldo-keto reductase KmAKR towards t-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate via semi-rational design.
Yu H; Qiu S; Cheng F; Cheng YN; Wang YJ; Zheng YG
Bioorganic chemistry 2019 · PubMed · DOI
Cite as: MarxBase result MARXBASE-R000635, release 1.0.