Characterization and modulation of endoplasmic reticulum stress response target genes in Kluyveromyces marxianus to improve secretory expressions of heterologous proteins.

Shi T; Zhou J; Xue A; Lu H; He Y; Yu Y
Biotechnology for biofuels 2021 · China · PubMed · DOI · PMC

Results (15 findings)

• ESR1 overexpression → decreases secretion of heterologous proteins − Negative
  host K. marxianus · Shi T 2021 · details
• HRD3 overexpression → decreases secretion of heterologous proteins − Negative
  host K. marxianus · Shi T 2021 · details
• USA1 overexpression → decreases secretion of heterologous proteins − Negative
  host K. marxianus · Shi T 2021 · details
• YET3 overexpression → decreases secretion of heterologous proteins − Negative
  host K. marxianus · Shi T 2021 · details
• YET3 deletion → no_effect secretion of heterologous proteins − Negative
  host K. marxianus · Shi T 2021 · details
• PDC1 overexpression → increases secretion of heterologous proteins + Positive
  host K. marxianus · Shi T 2021 · details
• PGK overexpression → increases secretion of heterologous proteins + Positive
  host K. marxianus · Shi T 2021 · details
• VID28 overexpression → increases secretion of heterologous proteins + Positive
  host K. marxianus · Shi T 2021 · details
• CAJ1 overexpression → increases secretion of heterologous proteins + Positive
  host K. marxianus · Shi T 2021 · details
• MET13 overexpression → increases secretion of heterologous proteins + Positive
  host K. marxianus · Shi T 2021 · details
• ESR1 deletion → increases secretion of heterologous proteins + Positive
  host K. marxianus · Shi T 2021 · details
• HRD3 deletion → increases secretion of heterologous proteins + Positive
  host K. marxianus · Shi T 2021 · details
• USA1 deletion → increases secretion of heterologous proteins + Positive
  host K. marxianus · Shi T 2021 · details
• HRD3 deletion → increases extracellular endoxylanase activity + Positive
  host K. marxianus · Shi T 2021 · 43% change vs wild type · details
• HRD3 deletion → increases extracellular glucanase activity + Positive
  host K. marxianus · Shi T 2021 · 28% change vs wild type · details

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